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Genet Res (Camb). 2008 Oct;90(5):421-31. doi: 10.1017/S0016672308009804.

A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila.

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  • 1Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK. b.vicoso@ed.ac.uk

Abstract

Population genetics models show that, under certain conditions, the X chromosome is expected to be under more efficient selection than the autosomes. This could lead to 'faster-X evolution', if a large proportion of mutations are fixed by positive selection, as suggested by recent studies in Drosophila. We used a multispecies approach to test this: Muller's element D, an autosomal arm, is fused to the ancestral X chromosome in Drosophila pseudoobscura and its sister species, Drosophila affinis. We tested whether the same set of genes had higher rates of non-synonymous evolution when they were X-linked (in the D. pseudoobscura/D. affinis comparison) than when they were autosomal (in Drosophila melanogaster/Drosophila yakuba). Although not significant, our results suggest this may be the case, but only for genes under particularly strong positive selection/weak purifying selection. They also suggest that genes that have become X-linked have higher levels of codon bias and slower synonymous site evolution, consistent with more effective selection on codon usage at X-linked sites.

PMID:
19061532
[PubMed - indexed for MEDLINE]

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