First isolation of two colistin-resistant emerging pathogens, Brevundimonas diminuta and Ochrobactrum anthropi, in a woman with cystic fibrosis: a case report

J Med Case Rep. 2008 Dec 5:2:373. doi: 10.1186/1752-1947-2-373.

Abstract

Introduction: Cystic fibrosis afflicted lungs support the growth of many bacteria rarely implicated in other cases of human infections.

Case presentation: We report the isolation and identification, by 16S rRNA amplification and sequencing, of two emerging pathogens resistant to colistin, Brevundimonas diminuta and Ochrobactrum anthropi, in a 17-year-old woman with cystic fibrosis and pneumonia. The patient eventually responded well to a 2-week regime of imipenem and tobramycin.

Conclusion: Our results clearly re-emphasize the emergence of new colistin-resistant pathogens in patients with cystic fibrosis.