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J Bacteriol. 2009 Feb;191(3):1115-7. doi: 10.1128/JB.01260-08. Epub 2008 Dec 5.

Chenodeoxycholate is an inhibitor of Clostridium difficile spore germination.

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  • 1Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.


Some cholate derivatives that are normal components of bile can act with glycine to induce the germination of Clostridium difficile spores, but at least one bile component, chenodeoxycholate, does not induce germination. Here we show that chenodeoxycholate inhibits the germination of C. difficile spores in response to cholate and taurocholate.

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