Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Med Clin North Am. 2009 Jan;93(1):45-66, x. doi: 10.1016/j.mcna.2008.08.007.

The contribution of genes to osteoarthritis.

Author information

  • 1Twin Research and Genetic Epidemiology Unit, St. Thomas Hospital Campus, Kings College, London School of Medicine, London SE1 7EH, UK. ana.valdes@kcl.ac.uk

Abstract

Osteoarthritis (OA) is the most prevalent form of arthritis in the elderly. A large body of evidence, including familial aggregation and classic twin studies, indicates that primary OA has a strong hereditary component that is likely polygenic in nature. Traits related to OA, such as longitudinal changes in cartilage volume and progression of radiographic features, are also under genetic control. In recent years several linkage analyses and candidate gene studies have been performed and unveiled some of the specific genes involved in disease risk, such as FRZB and GDF5. This article discusses the impact that future genome-wide association scans can have on our understanding of the pathogenesis of OA and on identifying individuals at high risk for developing severe OA.

PMID:
19059021
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk