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    Bioorg Med Chem. 2009 Mar 15;17(6):2215-8. Epub 2008 Nov 13.

    Antiproliferative cardenolide glycosides of Elaeodendron alluaudianum from the Madagascar Rainforest.

    Hou Y, Cao S, Brodie P, Callmander M, Ratovoson F, Randrianaivo R, Rakotobe E, Rasamison VE, Rakotonandrasana S, TenDyke K, Suh EM, Kingston DG.

    Source

    Department of Chemistry, Virginia Polytechnic Institute and State University, 3111 Hahn Hall, Blacksburg, M/C 0212, VA 24061-0212, USA.

    Abstract

    Bioassay-guided fractionation of an ethanol extract of a Madagascar collection of Elaeodendron alluaudianum led to the isolation of two new cardenolide glycosides (1 and 2). The (1)H and (13)C NMR spectra of both compounds were fully assigned using a combination of 2D NMR experiments, including (1)H-(1)H COSY, HSQC, HMBC, and ROESY sequences. Both compounds 1 and 2 were tested against the A2780 human ovarian cancer cell line and the U937 human histiocytic lymphoma cell line assays, and showed significant antiproliferative activity with IC(50) values of 0.12 and 0.07 microM against the A2780 human ovarian cancer cell line, and 0.15 and 0.08 microM against the U937 human histiocytic lymphoma cell line, respectively.

    PMID:
    19058971
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2860880
    Free PMC Article

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