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    Prostaglandins Leukot Essent Fatty Acids. 2009 Jan;80(1):9-18. Epub 2008 Dec 5.

    Proteomics-based approach to elucidate the mechanism of antitumor effect of curcumin in cervical cancer.

    Madden K, Flowers L, Salani R, Horowitz I, Logan S, Kowalski K, Xie J, Mohammed SI.

    Source

    Department of Comparative Pathobiology, Purdue University, 725 Harrison Street, West Lafayette, IN 47907, USA.

    Abstract

    Cervical cancer is the second leading cause of cancer death for women in the world. A potential target for preventing and treating cervical cancer is cyclooxygenase-2 (cox-2). Curcumin is an anti-inflammatory agent that is known to have anti-cox-2 activity. In this study we examined the expression of cox-2 in cervical cancer and its precursors by immunohistochemistry. The effect of curcumin in inhibiting cervical cancer cells was determined via 2-dimensional gel electrophoresis, data analysis, and ingenuity pathway analysis. No significant differences in the expression of cox-2 in squamous cell carcinoma, and carcinoma in situ were observed. However, there was a statistically significant difference in the expression of cox-2 in adenocarcinoma in comparison to normal (p value=0.01) and squamous cell carcinoma (p value=0.02) tissues. Proteins associated with cancer and cell cycle were significantly altered in cultured cells. Curcumin may have antitumor effect in cervical cancer.

    PMID:
    19058955
    [PubMed - indexed for MEDLINE]

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