Genes Dev. 2008 Dec 1;22(23):3232-5.

Master and commander: continued expression of Prox1 prevents the dedifferentiation of lymphatic endothelial cells.

Source

Max-Planck-Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, and University of Münster, Faculty of Medicine, Münster D-48149, Germany.

Abstract

Cell differentiation occurs mostly during a specific developmental time window and is irreversible. The homeobox-containing transcription factor Prox1 is a master regulator of lymphatic endothelial cell differentiation in the embryo. A study by Johnson et al. (3282-3291) published in this issue of Genes & Development now shows that continued expression of Prox1 is required to maintain lymphatic endothelial cell identity even in adult mice. These findings indicate that Prox1 is essential for the differentiation and function of the lymphatic vasculature throughout life.

Comment on

Genes Dev. 2008 Dec 1;22(23):3282-91.

PMID:: 19056879; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity. [Genes Dev. 2008]
Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity.
Johnson NC, Dillard ME, Baluk P, McDonald DM, Harvey NL, Frase SL, Oliver G. Genes Dev. 2008 Dec 1; 22(23):3282-91.
Review Prox1, master regulator of the lymphatic vasculature phenotype. [Cell Tissue Res. 2003]
Review Prox1, master regulator of the lymphatic vasculature phenotype.
Hong YK, Detmar M. Cell Tissue Res. 2003 Oct; 314(1):85-92. Epub 2003 Jul 22.
Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades. [Mol Biol Cell. 2007]
Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades.
Mishima K, Watabe T, Saito A, Yoshimatsu Y, Imaizumi N, Masui S, Hirashima M, Morisada T, Oike Y, Araie M, et al. Mol Biol Cell. 2007 Apr; 18(4):1421-9. Epub 2007 Feb 7.
Sox18 induces development of the lymphatic vasculature in mice. [Nature. 2008]
Sox18 induces development of the lymphatic vasculature in mice.
François M, Caprini A, Hosking B, Orsenigo F, Wilhelm D, Browne C, Paavonen K, Karnezis T, Shayan R, Downes M, et al. Nature. 2008 Dec 4; 456(7222):643-7. Epub 2008 Oct 19.
Review Lymphatic endothelial differentiation: start out with Sox--carry on with Prox. [Genome Biol. 2008]
Review Lymphatic endothelial differentiation: start out with Sox--carry on with Prox.
Kiefer F, Adams RH. Genome Biol. 2008; 9(12):243. Epub 2008 Dec 29.

See reviews... See all...

Cited by 2 PubMed Central articles

prox1b Activity is essential in zebrafish lymphangiogenesis. [PLoS One. 2010]
prox1b Activity is essential in zebrafish lymphangiogenesis.
Del Giacco L, Pistocchi A, Ghilardi A. PLoS One. 2010 Oct 18; 5(10):e13170. Epub 2010 Oct 18.
KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming. [Genes Dev. 2010]
KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming.
Hansen A, Henderson S, Lagos D, Nikitenko L, Coulter E, Roberts S, Gratrix F, Plaisance K, Renne R, Bower M, et al. Genes Dev. 2010 Jan 15; 24(2):195-205.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Master and commander: continued expression of Prox1 prevents the dedifferentiati...
Master and commander: continued expression of Prox1 prevents the dedifferentiation of lymphatic endothelial cells.
Genes Dev. 2008 Dec 1 ;22(23):3232-5.

PubMed
High concordance of KRAS status between primary colorectal tumors and related me...
High concordance of KRAS status between primary colorectal tumors and related metastatic sites: implications for clinical practice.
Oncologist. 2008 Dec ;13(12):1270-5. Epub 2008 Dec 4 .

PubMed
Motor control exercise for persistent, nonspecific low back pain: a systematic r...
Motor control exercise for persistent, nonspecific low back pain: a systematic review.
Phys Ther. 2009 Jan ;89(1):9-25. Epub 2008 Dec 4 .

PubMed
Resveratrol treatment in mice does not elicit the bradycardia and hypothermia as...
Resveratrol treatment in mice does not elicit the bradycardia and hypothermia associated with calorie restriction.
FASEB J. 2009 Apr ;23(4):1032-40. Epub 2008 Dec 4 .

PubMed
Interaction with Notch determines endocytosis of specific Delta ligands in zebra...
Interaction with Notch determines endocytosis of specific Delta ligands in zebrafish neural tissue.
Development. 2009 Jan ;136(2):197-206. Epub 2008 Dec 4 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: