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Neurobiol Dis. 2009 Feb;33(2):250-9. doi: 10.1016/j.nbd.2008.10.010. Epub 2008 Nov 6.

Aberrant differentiation of glutamatergic cells in neocortex of mouse model for fragile X syndrome.

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  • 1Neuroscience Center, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland.

Abstract

The lack of fragile X mental retardation protein (FMRP) causes fragile X syndrome, a common form of inherited mental retardation. Our previous studies revealed alterations in the differentiation of FMRP-deficient neural progenitors. Here, we show abnormalities in neurogenesis in the mouse and human embryonic FMRP-deficient brain as well as after in utero transfection of I304N mutated FMRP, which acts in a dominant negative manner in the wild-type mouse brain. Progenitors accumulated abnormally in the subventricular zone of the embryonic Fmr1-knockout (Fmr1-KO) mouse neocortex. An increased density of cells expressing sequentially an intermediate progenitor marker, T-box transcription factor (Tbr2), and a postmitotic neuron marker, T-brain 1 (Tbr1), indicated that the differentiation to glutamatergic cell lineages was particularly disturbed. These abnormalities were associated with an increased density of pyramidal cells of the layer V in the early postnatal neocortex suggesting a role for FMRP in the regulation of the differentiation of neocortical glutamatergic neurons.

PMID:
19056494
[PubMed - indexed for MEDLINE]
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