Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
BJOG. 2009 Jan;116(1):98-107. doi: 10.1111/j.1471-0528.2008.02001.x. Epub 2008 Dec 3.

Does leisure time physical activity in early pregnancy protect against pre-eclampsia? Prospective cohort in Danish women.

Author information

  • 1Maternal Nutrition Group, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. mae@ssi.dk

Abstract

OBJECTIVE:

To examine the association between physical activity in early pregnancy and risk of pre-eclampsia.

DESIGN:

Prospective cohort.

SETTING:

Denmark.

POPULATION:

A total of 85,139 pregnant Danish women, recruited between 1996 and 2002.

METHODS:

The authors assessed leisure time physical activity in first trimester by a telephone interview and categorised women a priori into seven groups: 0 (reference), 1-44, 45-74, 75-149, 150-269, 270-419 and 420+ minutes/week. Pre-eclampsia diagnoses were extracted from the Danish National Patient Registry. A number of potential confounders were adjusted for by logistic regression.

MAIN OUTCOME MEASURES:

Pre-eclampsia and severe pre-eclampsia.

RESULTS:

The two highest physical activity levels were associated with increased risk of severe pre-eclampsia compared with the nonexercising group, with adjusted odds ratios of 1.65 (95% CI: 1.11-2.43) and 1.78 (95% CI: 1.07-2.95), whereas more moderate levels of physical activity (1-270 minutes/week) had no statistically significant association with risk of pre-eclampsia (total n = 85,139).

CONCLUSIONS:

We were unable to document a protective effect of leisure time physical activity against pre-eclampsia. Our data even suggest that leisure time physical activity exceeding 270 minutes/week in first trimester may increase risk of severe pre-eclampsia.

PMID:
19055653
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Blackwell Publishing
    Loading ...
    Write to the Help Desk