Display Settings:

Format

Send to:

Choose Destination
Auton Neurosci. 2009 Jan 28;145(1-2):3-10. doi: 10.1016/j.autneu.2008.10.013. Epub 2008 Dec 2.

Diabetes and cardiovascular autonomic dysfunction: application of animal models.

Author information

  • 1Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH 45435, USA.

Abstract

When diabetes is associated with cardiovascular autonomic dysfunction, there is a poor prognosis and increased morbidity and mortality. Information on the mechanisms of diabetes-associated autonomic dysfunction has been provided by advanced studies using physiological, pharmacological, anatomical and molecular methods in experimental animal models of insulin deficiency and resistance. This has been augmented by new approaches which combine diabetes induction with genetically modified animal models. The aim of this review is to outline and discuss the animal models used for the study of insulin deficiency and insulin resistance with a focus on autonomic neural interactions. The goal is to better understand the clinical relevance of cardiovascular autonomic dysfunction associated with diabetes.

PMID:
19054720
[PubMed - indexed for MEDLINE]
PMCID:
PMC2659465
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk