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Org Lett. 2009 Jan 1;11(1):225-8. doi: 10.1021/ol8024814.

Antibacterial neurymenolides from the Fijian red alga Neurymenia fraxinifolia.

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  • 1School of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, 30332, USA.


Two novel alpha-pyrone macrolides, neurymenolides A (1) and B (2), were isolated from the Fijian red alga Neurymenia fraxinifolia and characterized using a combination of NMR and mass spectral analyses. These molecules represent only the second example of alpha-pyrone macrolides, with 1 existing as interchanging atropisomers due to restricted rotation about the alpha-pyrone ring system. Neurymenolide A (1) displayed moderately potent activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREF).

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