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Indian J Dermatol Venereol Leprol. 2008 Sep-Oct;74(5):490-2.

Donovanosis with auto-amputation of penis in a HIV-2 infected person.

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  • 1Department of STD, Rangaraya Medical College, Government General Hospital, Kakinada, Andhra Pradesh, India. drchandragupta_ts@rediffmail.com

Abstract

Donovanosis is a slowly progressive, granulomatous ulcerative disease , caused by Klebsiella (Calymmatobacterium) granulomatis. The disease is known to persist for years together, leading to complications. A male patient aged 30 years with underlying HIV-2 infection presented to the department of STD with painful ulceration over the genital region of 5 months duration, with absence of penis. Tissue smear from the ulcer and histopathological examination revealed large histiocytes with intracellular Donovan bodies (Pund cell). A final diagnosis of donovanosis with auto-amputation of penis with HIV-2 infection was made. The old conventional medicines, viz. streptomycin, doxycycline and amoxycillin, were effective. Though HIV-2 infections are milder than HIV-1 infections in all aspects, donovanosis in this HIV-2 infected case presented with complications. However, since the CD4 count was 748 cells/cmm, the severity is attributed to the long standing nature and negligence by the patient, and not to possible immunodeficiency.

PMID:
19052412
[PubMed - indexed for MEDLINE]
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