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Nat Rev Neurosci. 2009 Jan;10(1):48-58. doi: 10.1038/nrn2536. Epub 2008 Dec 3.

Perceiving is believing: a Bayesian approach to explaining the positive symptoms of schizophrenia.

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  • 1University of Cambridge, Department of Psychiatry, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK.


Advances in cognitive neuroscience offer us new ways to understand the symptoms of mental illness by uniting basic neurochemical and neurophysiological observations with the conscious experiences that characterize these symptoms. Cognitive theories about the positive symptoms of schizophrenia--hallucinations and delusions--have tended to treat perception and belief formation as distinct processes. However, recent advances in computational neuroscience have led us to consider the unusual perceptual experiences of patients and their sometimes bizarre beliefs as part of the same core abnormality--a disturbance in error-dependent updating of inferences and beliefs about the world. We suggest that it is possible to understand these symptoms in terms of a disturbed hierarchical Bayesian framework, without recourse to separate considerations of experience and belief.

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