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J Lipid Res. 2009 Apr;50 Suppl:S364-9. doi: 10.1194/jlr.R800092-JLR200. Epub 2008 Dec 2.

The role of adaptive T cell immunity in atherosclerosis.

Author information

  • 1Paris Cardiovascular Research Center, INSERM and Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, 75015 Paris, France. ziad.mallat@inserm.fr

Abstract

There is now solid evidence that T cell adaptive immunity is involved in atherogenesis. While initial studies have focused on the pathogenic arm of the immune response, more recent work clearly suggests an important role for several subsets of regulatory T cells in the protection against lesion development. Here, we review the current knowledge on the role of both pathogenic and regulatory adaptive T cell immunity in atherosclerosis, generated mainly from the study of mouse models of the disease.

PMID:
19050311
[PubMed - indexed for MEDLINE]
PMCID:
PMC2674704
Free PMC Article

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