Exp Brain Res. 2009 Mar;193(4):491-500. Epub 2008 Dec 2.

The monosynaptic Ia afferent pathway can largely explain the stretch duration effect of the long latency M2 response.

Schuurmans J, de Vlugt E, Schouten AC, Meskers CG, de Groot JH, van der Helm FC.

Source

Laboratory for Neuromuscular Control, Department of Biomechanical Engineering, Delft University of Technology, Mekelweg 2, 2628 CD Delft, The Netherlands. j.schuurmans@tudelft.nl

Abstract

Sudden stretch of active muscle typically results in two characteristic electromyographic responses: the short latency M1 and the long latency M2. The M1 response originates from the monosynaptic Ia afferent reflex pathway. The M2 response is less well understood and is likely a compound response to different afferent inputs mediated by spinal and transcortical pathways. In this study the possible contribution of the Ia afferent pathway to the M2 response was investigated. A mechanism was hypothesized in which the M1 response synchronizes the motoneurons, and therewith their refractory periods. Stretch perturbation experiments were performed on the wrist and results were compared with a computational model of a pool of motoneurons receiving tonic and Ia afferent input. The simulations showed the same stretch amplitude, velocity, and duration-dependent characteristics on the M2 as found experimentally. It was concluded that the stretch duration effect of the M2 likely originates from the proposed Ia afferent mediated mechanism.

PMID:: 19048240; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

The influence of perturbation duration and velocity on the long-latency response to stretch in the biceps muscle. [Exp Brain Res. 2005]
The influence of perturbation duration and velocity on the long-latency response to stretch in the biceps muscle.
Lewis GN, Perreault EJ, MacKinnon CD. Exp Brain Res. 2005 Jun; 163(3):361-9. Epub 2005 Jan 15.
Tizanidine does not affect the linear relation of stretch duration to the long latency M2 response of m. flexor carpi radialis. [Exp Brain Res. 2010]
Tizanidine does not affect the linear relation of stretch duration to the long latency M2 response of m. flexor carpi radialis.
Meskers CG, Schouten AC, Rich MM, de Groot JH, Schuurmans J, Arendzen JH. Exp Brain Res. 2010 Apr; 201(4):681-8. Epub 2009 Nov 26.
Responses of human masseter motor units to stretch. [J Physiol. 1995]
Responses of human masseter motor units to stretch.
Miles TS, Poliakov AV, Nordstrom MA. J Physiol. 1995 Feb 15; 483 ( Pt 1):251-64.
Review Skeletal muscle tone and the misunderstood stretch reflex. [Neurology. 1992]
Review Skeletal muscle tone and the misunderstood stretch reflex.
Davidoff RA. Neurology. 1992 May; 42(5):951-63.
Review Central control components of a 'simple' stretch reflex. [Trends Neurosci. 2000]
Review Central control components of a 'simple' stretch reflex.
Clarac F, Cattaert D, Le Ray D. Trends Neurosci. 2000 May; 23(5):199-208.

See reviews... See all...

Cited by 3 PubMed Central articles

Neurophysiologic effects of spinal manipulation in patients with chronic low back pain. [BMC Musculoskelet Disord. 2011]
Neurophysiologic effects of spinal manipulation in patients with chronic low back pain.
Clark BC, Goss DA Jr, Walkowski S, Hoffman RL, Ross A, Thomas JS. BMC Musculoskelet Disord. 2011 Jul 22; 12:170. Epub 2011 Jul 22.
Control of wrist position and muscle relaxation by shifting spatial frames of reference for motoneuronal recruitment: possible involvement of corticospinal pathways. [J Physiol. 2010]
Control of wrist position and muscle relaxation by shifting spatial frames of reference for motoneuronal recruitment: possible involvement of corticospinal pathways.
Raptis H, Burtet L, Forget R, Feldman AG. J Physiol. 2010 May 1; 588(Pt 9):1551-70. Epub 2010 Mar 15.
Tizanidine does not affect the linear relation of stretch duration to the long latency M2 response of m. flexor carpi radialis. [Exp Brain Res. 2010]
Tizanidine does not affect the linear relation of stretch duration to the long latency M2 response of m. flexor carpi radialis.
Meskers CG, Schouten AC, Rich MM, de Groot JH, Schuurmans J, Arendzen JH. Exp Brain Res. 2010 Apr; 201(4):681-8. Epub 2009 Nov 26.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The monosynaptic Ia afferent pathway can largely explain the stretch duration ef...
The monosynaptic Ia afferent pathway can largely explain the stretch duration effect of the long latency M2 response.
Exp Brain Res. 2009 Mar ;193(4):491-500. Epub 2008 Dec 2 .

PubMed
[Medical-oncological aspects in the treatment of pancreatic cancer].
[Medical-oncological aspects in the treatment of pancreatic cancer].
Radiologe. 2009 Feb ;49(2):144-8.

PubMed
Nucleic acids-based therapeutics in the battle against pathogenic viruses.
Nucleic acids-based therapeutics in the battle against pathogenic viruses.
Handb Exp Pharmacol. 2009 ;(189):243-63.

PubMed
A mammary-specific, long-range deletion on mouse chromosome 11 accelerates Brca1...
A mammary-specific, long-range deletion on mouse chromosome 11 accelerates Brca1-associated mammary tumorigenesis.
Neoplasia. 2008 Dec ;10(12):1325-34.

PubMed
Sampling-based approaches to improve estimation of mortality among patient dropo...
Sampling-based approaches to improve estimation of mortality among patient dropouts: experience from a large PEPFAR-funded program in Western Kenya.
PLoS One. 2008 ;3(12):e3843. Epub 2008 Dec 2 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: