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Br J Clin Pharmacol. 1991 Feb;31(2):193-6.

A dose-response study examining the effects of ritanserin on human slow wave sleep.

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  • 1Clinical Pharmacology Unit, Janssen Research Foundation, Wantage, Oxon.

Abstract

This study investigated the effects of placebo, 1 mg, 3 mg, 10 mg and 30 mg ritanserin and 10 mg diazepam on human sleep. Twelve normal volunteers participated in this randomized, double-blind, placebo-controlled cross-over sleep study. A clear dose-response relationship was found for ritanserin with higher doses evoking increased duration of slow wave sleep.

PMID:
1904750
PMCID:
PMC1368392
[PubMed - indexed for MEDLINE]
Free PMC Article
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