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IET Syst Biol. 2008 Sep;2(5):206-21. doi: 10.1049/iet-syb:20070075.

Network integration and graph analysis in mammalian molecular systems biology.

Author information

  • Mount Sinai School of Medicine, Department of Pharmacology and Systems Therapeutics, New York, NY 10029-6574, USA. avi.maayan@mssm.edu

Abstract

Abstraction of intracellular biomolecular interactions into networks is useful for data integration and graph analysis. Network analysis tools facilitate predictions of novel functions for proteins, prediction of functional interactions and identification of intracellular modules. These efforts are linked with drug and phenotype data to accelerate drug-target and biomarker discovery. This review highlights the currently available varieties of mammalian biomolecular networks, and surveys methods and tools to construct, compare, integrate, visualise and analyse such networks.

PMID:
19045817
[PubMed - indexed for MEDLINE]
PMCID:
PMC2745214
Free PMC Article

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