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Nat Cell Biol. 2008 Dec;10(12):1387-8. doi: 10.1038/ncb1208-1387.

Staying alive: apoptosome feedback inhibition.

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  • 1Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. steller@rockefeller.edu

Abstract

Studies in Drosophila melanogaster reveal a mechanism for regulating caspases, the key executioners of the apoptotic cell-death program. An initiator caspase and its activating partner promote degradation of each other, thereby limiting the levels of the active protease complex. This negative-feedback inhibition helps to explain how cells avoid unwanted caspase activation and apoptosis.

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