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Nat Cell Biol. 2008 Dec;10(12):1385-7. doi: 10.1038/ncb1208-1385.

Under arrest in mitosis: Cdc20 dies twice.

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  • 1Department of Biochemistry, University of Leicester, Leicester LE1 9HN, UK. amf5@le.ac.uk

Abstract

The spindle assembly checkpoint is crucial for maintaining genome integrity in dividing cells by preventing premature chromosome segregation. Degradation of the APC/C activator Cdc20 seems to be an essential and conserved mechanism to maintain this checkpoint in the presence of chromosomes that are not attached to the mitotic spindle.

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PMID:
19043431
[PubMed - indexed for MEDLINE]
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