Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Nat Cell Biol. 2008 Dec;10(12):1385-7. doi: 10.1038/ncb1208-1385.

Under arrest in mitosis: Cdc20 dies twice.

Author information

  • 1Department of Biochemistry, University of Leicester, Leicester LE1 9HN, UK. amf5@le.ac.uk


The spindle assembly checkpoint is crucial for maintaining genome integrity in dividing cells by preventing premature chromosome segregation. Degradation of the APC/C activator Cdc20 seems to be an essential and conserved mechanism to maintain this checkpoint in the presence of chromosomes that are not attached to the mitotic spindle.

Comment on

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk