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Nat Cell Biol. 2008 Dec;10(12):1385-7. doi: 10.1038/ncb1208-1385.

Under arrest in mitosis: Cdc20 dies twice.

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  • 1Department of Biochemistry, University of Leicester, Leicester LE1 9HN, UK.


The spindle assembly checkpoint is crucial for maintaining genome integrity in dividing cells by preventing premature chromosome segregation. Degradation of the APC/C activator Cdc20 seems to be an essential and conserved mechanism to maintain this checkpoint in the presence of chromosomes that are not attached to the mitotic spindle.

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