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Cell Stem Cell. 2008 Dec 4;3(6):583-6. doi: 10.1016/j.stem.2008.11.002.

Overcoming obstacles in the search for the site of hematopoietic stem cell emergence.

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  • 1Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Abstract

The murine embryo has become a valuable tool to examine the ontogeny of hematopoiesis. However, the onset of the systemic circulation has long been a confounding developmental variable that may mask the site of blood cell emergence. This Minireview examines some approaches that have been applied to overcome this obstacle.

PMID:
19041773
[PubMed - indexed for MEDLINE]
PMCID:
PMC2756073
Free PMC Article
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