Cell Stem Cell. 2008 Dec 4;3(6):575-6.

ALS model glia can mediate toxicity to motor neurons derived from human embryonic stem cells.

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Department of Cell and Molecular Biology, Ludwig Institute for Cancer Research, Karolinska Institute, Nobelsv 3, 171 77 Stockholm, Sweden. eva.hedlund@licr.ki.se

Abstract

In this issue of Cell Stem Cell, Di Giorgio et al. (2008) and Marchetto et al. (2008) culture motor neurons derived from human embryonic stem cells with astrocytes expressing mutant SOD1. In these human ALS models, motor neurons are selectively destroyed by mutant astrocyte-secreted factors, and potential neuroprotective pathways are revealed.

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PMID:: 19041769; [PubMed - indexed for MEDLINE]

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Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. [Cell Stem Cell. 2008]
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Marchetto MC, Muotri AR, Mu Y, Smith AM, Cezar GG, Gage FH. Cell Stem Cell. 2008 Dec 4; 3(6):649-57.
Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation. [Cell Stem Cell. 2008]
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Nagai M, Re DB, Nagata T, Chalazonitis A, Jessell TM, Wichterle H, Przedborski S. Nat Neurosci. 2007 May; 10(5):615-22. Epub 2007 Apr 15.
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Review Fas(t) balls and Lou Gehrig disease. A clue to selective vulnerability of motor neurons?
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Cited by 2 PubMed Central articles

Global gene expression profiling of somatic motor neuron populations with different vulnerability identify molecules and pathways of degeneration and protection. [Brain. 2010]
Global gene expression profiling of somatic motor neuron populations with different vulnerability identify molecules and pathways of degeneration and protection.
Hedlund E, Karlsson M, Osborn T, Ludwig W, Isacson O. Brain. 2010 Aug; 133(Pt 8):2313-30.
Review Stem cell-derived motor neurons: applications and challenges in amyotrophic lateral sclerosis. [Curr Stem Cell Res Ther. 2009]
Review Stem cell-derived motor neurons: applications and challenges in amyotrophic lateral sclerosis.
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