Best Pract Res Clin Haematol. 2008 Dec;21(4):615-20.

Can we finally target the leukemic stem cells?

Source

James P. Wilmot Cancer Center, University of Rochester School of Medicine, 601 Elmwood Avenue, Box 704, Rochester, NY 14642, USA. craig_jordan@urmc.rochester.edu

Abstract

Two key issues must be addressed in the discussion of targeting leukemic stem cells: (1) can the leukemic stem cell be targeted in vivo, and (2) how to assess whether the leukemic stem cell is actually being targeted. Currently several small molecule and antibody- or ligand-based agents have shown activity in selectively targeting the leukemic stem cell. However, there is debate about how to use these targeted agents and how to identify and quantitate the leukemic stem cell to determine whether or not it is being targeted. Parameters are suggested here to help identify and quantitate leukemic stem cells in the clinical context.

PMID:: 19041600; [PubMed - indexed for MEDLINE]
PMCID: PMC2613248

Free PMC Article

Images from this publication.See all images (2) Free text

MeSH Terms, Substances, Grant Support

MeSH Terms

Substances

Biological Markers

Grant Support

R01 CA090446-05/CA/NCI NIH HHS/United States

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Leukemia - MedlinePlus Health Information

Supplemental Content

Related citations

Review Targeting the leukemic stem cell: the Holy Grail of leukemia therapy. [Leukemia. 2009]
Review Targeting the leukemic stem cell: the Holy Grail of leukemia therapy.
Misaghian N, Ligresti G, Steelman LS, Bertrand FE, Bäsecke J, Libra M, Nicoletti F, Stivala F, Milella M, Tafuri A, et al. Leukemia. 2009 Jan; 23(1):25-42. Epub 2008 Sep 18.
Review The leukemic stem cell. [Best Pract Res Clin Haematol. 2007]
Review The leukemic stem cell.
Jordan CT. Best Pract Res Clin Haematol. 2007 Mar; 20(1):13-8.
Review Targeting the acute myeloid leukemia stem cells. [Anticancer Agents Med Chem. 2010]
Review Targeting the acute myeloid leukemia stem cells.
Krause A, Luciana M, Krause F, Rego EM. Anticancer Agents Med Chem. 2010 Feb; 10(2):104-10.
Review Right on target: eradicating leukemic stem cells. [Trends Mol Med. 2007]
Review Right on target: eradicating leukemic stem cells.
Krause DS, Van Etten RA. Trends Mol Med. 2007 Nov; 13(11):470-81. Epub 2007 Nov 5.
Review Considerations for targeting malignant stem cells in leukemia. [Cancer Control. 2004]
Review Considerations for targeting malignant stem cells in leukemia.
Guzman ML, Jordan CT. Cancer Control. 2004 Mar-Apr; 11(2):97-104.

See reviews... See all...

Cited by 1 PubMed Central article

Differential destruction of stem cells: implications for targeted cancer stem cell therapy. [Cancer Res. 2009]
Differential destruction of stem cells: implications for targeted cancer stem cell therapy.
Sehl ME, Sinsheimer JS, Zhou H, Lange KL. Cancer Res. 2009 Dec 15; 69(24):9481-9.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Can we finally target the leukemic stem cells?
Can we finally target the leukemic stem cells?
Best Pract Res Clin Haematol. 2008 Dec ;21(4):615-20.

PubMed
Insulin-like growth factor-1 induces lipid production in human SEB-1 sebocytes v...
Insulin-like growth factor-1 induces lipid production in human SEB-1 sebocytes via sterol response element-binding protein-1.
J Invest Dermatol. 2006 Jun ;126(6):1226-32.

PubMed
A cell initiating human acute myeloid leukaemia after transplantation into SCID ...
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice.
Nature. 1994 Feb 17 ;367(6464):645-8.

PubMed
Aloe vera in dermatology: a brief review.
Aloe vera in dermatology: a brief review.
G Ital Dermatol Venereol. 2009 Feb ;144(1):85-91.

PubMed
Structure elucidation of a senescence cross-link from human extracellular matrix...
Structure elucidation of a senescence cross-link from human extracellular matrix. Implication of pentoses in the aging process.
J Biol Chem. 1989 Dec 25 ;264(36):21597-602.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: