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Phytochemistry. 2009 Jan;70(1):53-9. doi: 10.1016/j.phytochem.2008.10.010. Epub 2008 Nov 27.

Arabidopsis 3-hydroxy-3-methylglutaryl-CoA reductase is regulated at the post-translational level in response to alterations of the sphingolipid and the sterol biosynthetic pathways.

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  • 1Departament de Bioquímica i Biologia Molecular, Facultat de Farmacia, Universitat de Barcelona, Avda. Diagonal 643, 08028 Barcelona, Spain.


3-Hydroxy-3-methylglutaryl-CoA reductase (HMGR, EC catalyzes the major rate-limiting step in the mevalonate (MVA) pathway for isoprenoid biosynthesis. Its activity is regulated at different levels, from transcriptional to post-translational. Treatment of Arabidopsis thaliana plants with myriocin, a specific inhibitor of serine palmitoyltransferase (SPT), the first enzyme of sphingolipid biosynthesis, resulted in a concomitant reduction of both HMGR activity and the sterol content, which reveals regulatory cross-talk between these two lipid biosynthesis pathways. Myriocin-induced down-regulation of HMGR activity is exerted at the post-translational level, like the regulatory response of HMGR to enhancement or depletion of the flux through the sterol pathway.

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