Do we use the appropriate controls for the identification of informative methylation markers for early cancer detection?

Yasser Riazalhosseini; Jörg D Hoheisel

doi:10.1186/gb-2008-9-11-405

Do we use the appropriate controls for the identification of informative methylation markers for early cancer detection?

Genome Biol. 2008;9(11):405. doi: 10.1186/gb-2008-9-11-405. Epub 2008 Nov 26.

Authors

Yasser Riazalhosseini, Jörg D Hoheisel

Abstract

It is possible to miss potential DNA methylation markers of tumorigenesis because of the initial filtering of profiling results on the basis of inappropriate controls.

Publication types

Letter

MeSH terms

Breast Neoplasms / diagnosis*
Breast Neoplasms / genetics*
DNA Methylation
DNA, Neoplasm / genetics
Early Detection of Cancer
Female
Humans

Substances

DNA, Neoplasm