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    Clin Vaccine Immunol. 2009 Feb;16(2):285-7. Epub 2008 Nov 26.

    Difference between the abilities of human Fcgamma receptor-expressing CV-1 cells to neutralize American and Asian genotypes of dengue virus 2.

    Source

    Department of Pathology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.

    Abstract

    Sera from patients involved in a Peruvian outbreak of dengue virus serotype 1 infection cross-neutralized the American genotype of dengue virus serotype 2 up to 100-fold more efficiently than they did the virulent Asian genotype of dengue virus serotype 2, as determined by a plaque reduction neutralization test (PRNT) with CV-1 fibroblasts modified to express human Fcgamma receptor CD32. The concordant preferential immune enhancement of the Asian genotype of dengue virus serotype 2 in human monocytes suggests that such a modification might strengthen the correlation between the PRNT titer and protection.

    PMID:
    19038781
    [PubMed - indexed for MEDLINE]
    PMCID: PMC2643537
    Free PMC Article

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