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J Virol. 2009 Feb;83(3):1532-7. doi: 10.1128/JVI.01937-08. Epub 2008 Nov 26.

Recombinant canine coronaviruses related to transmissible gastroenteritis virus of Swine are circulating in dogs.

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  • 1Department of Public Health and Animal Sciences, Faculty of Veterinary Medicine, Valenzano (Bari), Italy.


Four canine coronavirus type II (CCoV-II) strains were identified in the guts and internal organs of pups which had died of acute gastroenteritis. The CCoV-II strains were strictly related to porcine transmissible gastroenteritis virus (TGEV) in the N-terminal domain of the spike protein, whereas in the other parts of the genome, a higher genetic relatedness to recent CCoV-II isolates was observed. Experimental infection of dogs with a TGEV-like isolate induced mild gastroenteritis without any systemic involvement. By virus neutralization tests, antigenic differences between reference and TGEV-like CCoVs were found. Our data support the potential recombinant origin of the TGEV-like CCoVs.

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