The human pre-B-specific lambda-like cluster is lo...[Genomics. 1991]

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1: Genomics. 1991 Mar;9(3):544-6. Links

The human pre-B-specific lambda-like cluster is located in the 22q11.2-22q12.3 region, distal to the IgC lambda locus.

Mattei MG, Fumoux F, Roeckel N, Fougereau M, Schiff C.

Centre de Génétique de la Timone, Hôpital d'Enfants, Marseille, France.

The chromosomal location of the lambda-like gene cluster, a gene family selectively expressed in human pre-B cells, was analyzed by in situ hybridization with a probe specific for the lambda-like genes. This cluster mapped in the q11.2-q12.3 region of chromosome 22. The use of Burkitt lymphoma and myelogenous leukemia cell lines with translocations in the 22q11 region led to a refinement in the location according to the following order: cen----BCRL2, VpreB, IgV lambda 1----BCRL4, IgV lambda----IgC lambda----BCR----BCRL3, lambda-like----tel. Unlike those of the mouse system, the pre-B-specific genes VpreB and lambda-like do not belong to the same transcriptional unit.

PMID: 1903358 [PubMed - indexed for MEDLINE]

The human Vpre B gene is located on chromosome 22 near a cluster of V lambda gene segments.
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[Immunogenetics. 1993]
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Int Immunol. 1991 Nov; 3(11):1081-90.

[Int Immunol. 1991]
In situ hybridization and translocation breakpoint mapping. II. Two unusual t(21;22) translocations.
Cytogenet Cell Genet. 1985; 39(3):173-8.

[Cytogenet Cell Genet. 1985]
ReviewNew genetics of Burkitt's lymphoma and other non-Hodgkin's lymphomas.
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[Am J Med. 1984]
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Cited by 1 PubMed Central article

Comparative mapping of the human 22q11 chromosomal region and the orthologous region in mice reveals complex changes in gene organization.
Puech A, Saint-Jore B, Funke B, Gilbert DJ, Sirotkin H, Copeland NG, Jenkins NA, Kucherlapati R, Morrow B, Skoultchi AI. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14608-13.

[Proc Natl Acad Sci U S A. 1997]

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The human pre-B-specific lambda-like cluster is located in the 22q11.2-22q12.3 region, dis...The human pre-B-specific lambda-like cluster is located in the 22q11.2-22q12.3 region, distal to the IgC lambda locus.

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The human pre-B-specific lambda-like cluster is located in the 22q11.2-22q12.3 region, distal to the IgC lambda locus.

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