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Nat Rev Immunol. 2008 Dec;8(12):935-47. doi: 10.1038/nri2455.

Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells.

Author information

  • 1Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA. Miriam.Merad@mssm.edu

Abstract

Langerhans cells (LCs) are a specialized subset of dendritic cells (DCs) that populate the epidermal layer of the skin. Langerin is a lectin that serves as a valuable marker for LCs in mice and humans. In recent years, new mouse models have led to the identification of other langerin(+) DC subsets that are not present in the epidermis, including a subset of DCs that is found in most non-lymphoid tissues. In this Review we describe new developments in the understanding of the biology of LCs and other langerin(+) DCs and discuss the challenges that remain in identifying the role of different DC subsets in tissue immunity.

PMID:
19029989
[PubMed - indexed for MEDLINE]
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