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    Nat Rev Immunol. 2008 Dec;8(12):935-47.

    Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells.

    Merad M, Ginhoux F, Collin M.

    Source

    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA. Miriam.Merad@mssm.edu

    Abstract

    Langerhans cells (LCs) are a specialized subset of dendritic cells (DCs) that populate the epidermal layer of the skin. Langerin is a lectin that serves as a valuable marker for LCs in mice and humans. In recent years, new mouse models have led to the identification of other langerin(+) DC subsets that are not present in the epidermis, including a subset of DCs that is found in most non-lymphoid tissues. In this Review we describe new developments in the understanding of the biology of LCs and other langerin(+) DCs and discuss the challenges that remain in identifying the role of different DC subsets in tissue immunity.

    PMID:
    19029989
    [PubMed - indexed for MEDLINE]

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