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Nat Biotechnol. 2008 Dec;26(12):1364-6. doi: 10.1038/nbt.1509. Epub 2008 Nov 23.

Human embryonic stem cells reveal recurrent genomic instability at 20q11.21.

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  • 1INSERM/UEVE UMR-861, I-STEM, AFM, Institute for Stem cell Therapy and Exploration of Monogenic diseases, 5 rue Henri Desbruères, 91030 Evry cedex, France.


By analyzing five human embryonic stem (hES) cell lines over long-term culture, we identified a recurrent genomic instability in the human genome. An amplification of 2.5-4.6 Mb at 20q11.21, encompassing approximately 23 genes in common, was detected in four cell lines of different origins. This amplification, which has been associated with oncogenic transformation, may provide a selective advantage to hES cells in culture.

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