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Nat Immunol. 2009 Jan;10(1):116-25. doi: 10.1038/ni.1688. Epub 2008 Nov 23.

Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans.

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  • 1Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA.

Abstract

A major challenge in vaccinology is to prospectively determine vaccine efficacy. Here we have used a systems biology approach to identify early gene 'signatures' that predicted immune responses in humans vaccinated with yellow fever vaccine YF-17D. Vaccination induced genes that regulate virus innate sensing and type I interferon production. Computational analyses identified a gene signature, including complement protein C1qB and eukaryotic translation initiation factor 2 alpha kinase 4-an orchestrator of the integrated stress response-that correlated with and predicted YF-17D CD8(+) T cell responses with up to 90% accuracy in an independent, blinded trial. A distinct signature, including B cell growth factor TNFRS17, predicted the neutralizing antibody response with up to 100% accuracy. These data highlight the utility of systems biology approaches in predicting vaccine efficacy.

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  • Rules to 'prime' by. [Nat Immunol. 2009]
PMID:
19029902
[PubMed - indexed for MEDLINE]
PMCID:
PMC4049462
Free PMC Article
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