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Nat Neurosci. 2009 Jan;12(1):29-31. doi: 10.1038/nn.2224. Epub 2008 Nov 23.

Reduced structural connectivity in ventral visual cortex in congenital prosopagnosia.

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  • 1Department of Psychology, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, USA.


Using diffusion tensor imaging and tractography, we found that a disruption in structural connectivity in ventral occipito-temporal cortex may be the neurobiological basis for the lifelong impairment in face recognition that is experienced by individuals who suffer from congenital prosopagnosia. Our findings suggest that white-matter fibers in ventral occipito-temporal cortex support the integrated function of a distributed cortical network that subserves normal face processing.

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