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J Lipid Res. 2009 Apr;50 Suppl:S335-9. doi: 10.1194/jlr.R800059-JLR200. Epub 2008 Nov 23.

Diabetes and atherosclerosis: is there a role for hyperglycemia?

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  • 1Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington School of Medicine, Seattle, WA 98109, USA.


Atherosclerosis is accelerated in both type 1 and type 2 diabetes. The hallmark of diabetes is the presence of hyperglycemia. In this article, we review the role of glucose in the pathogenesis of atherosclerosis. Evidence obtained from epidemiological, in vitro, and animal studies will be reviewed in an attempt to understand the complex relationship between hyperglycemia and cardiovascular risk that is emerging from clinical trials.

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