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J Bacteriol. 2009 Feb;191(3):1097-100. doi: 10.1128/JB.00862-08. Epub 2008 Nov 21.

Growth conditions regulate the requirements for Caulobacter chromosome segregation.

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  • 1Department of Molecular Biology, Princeton University, Washington Rd., Princeton, NJ 08544, USA.


Growth environments are important metabolic and developmental regulators. Here we demonstrate a growth environment-dependent effect on Caulobacter chromosome segregation of a small-molecule inhibitor of the MreB bacterial actin cytoskeleton. Our results also implicate ParAB as important segregation determinants, suggesting that multiple distinct mechanisms can mediate Caulobacter chromosome segregation and that their relative contributions can be environmentally regulated.

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