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    Reumatizam. 2008;55(2):70-2.

    [Rituximab (Mabthera)--treatment of rheumatoid arthritis patients with inadequate response to TNF inhibitors--when to change therapy?].

    [Article in Croatian]
    Morović-Vergles J.

    Source

    Zavod za klinicku imunologiju i reumatologiju, Klinika za unutarnje bolesti Klinicka bolnica "Dubrava", 10000 Zagreb.

    Abstract

    B cells play a critical role in the pathogenesis of rheumatoid arthritis. Recently, a number of biological agents that target B cells have been tested as therapies for these conditions. Of this group of agents, the first in clinical use has been rituximab, a chimeric monoclonal antibody that depletes B cells by binding to the CD20 cell-surface antigen. 25-40% of patients treated with a TNF inhibitor fail to achieve adequate response. A treatment response is inadequate if low disease activity or remission is not achieved. Treatment of patients with inadequate response to TNF inhibitors represents a challenge. What are the options? Switch to another anti-TNFalpha agent or initiate treatment with a biological agent with a different mechanism of action? In patients with persistent active disease despite anti-TNFalpha therapy, treatment with rituximab may be more effective than switching to another anti-TNFalpha.

    PMID:
    19024280
    [PubMed - indexed for MEDLINE]

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