Format

Send to

Choose Destination
See comment in PubMed Commons below
Eur J Cancer. 2008 Dec;44(18):2753-9. doi: 10.1016/j.ejca.2008.09.037. Epub 2008 Nov 18.

MicroRNA profiling as a tool to understand prognosis, therapy response and resistance in breast cancer.

Author information

  • 1Molecular Biology Unit, Department of Experimental Oncology, Fondazione IRCCS, Istituto Nazionale Tumori, Milano, Italy.

Abstract

Despite advances in detection and therapies, breast cancer is still the leading cause of cancer death in women worldwide. The etiology of this neoplasm is complex, and both genetic and environmental factors contribute to the complicated scenario. Gene profiling studies have been extensively used over the past decades as a powerful tool in defining the signature of different cancers and in predicting outcome and response to therapies. More recently, a new class of small non-coding RNAs, microRNAs (miRNAs), able to regulate gene expression binding seed sequences on the 3'UTR of mRNA targets, has been linked to several human diseases, including cancer. An increasing amount of experimental evidence shows that miRNAs are aberrantly expressed in different tumour types, and that they can have a causal role in tumourigenesis. Here, we describe and discuss the evidence supporting the association between miRNAs and breast cancer, underlining their role in the development of this neoplasia, and the impact on putative innovative therapeutical approaches.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk