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J Biomed Opt. 2008 Sep-Oct;13(5):054048. doi: 10.1117/1.2983676.

Analysis of hollow-core photonic bandgap fibers for evanescent wave biosensing.

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  • 1Nanyang Technological University, School of Chemical and Biomedical Engineering, Division of Bioengineering, Singapore, 637457.


Hollow-core photonic bandgap fiber (HC-PBGF)-based evanescent wave biosensors are demonstrated and analyzed theoretically and experimentally. With 95% of the guided light power residing in the samples, the measured absorbance for a 30-cm-long fiber filled with a 0.2 microM Alexa Fluor 700-labeled DNA Oligo solution is 1.06. This is in good agreement with the theoretical prediction, which is evaluated by using the refractive index scaling law. The HC-PBGFs thus offer both efficiency and simplicity for the detection of biomolecules in ultra-small sample volumes.

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