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    Biochem Biophys Res Commun. 1991 Mar 15;175(2):451-8.

    A hemopoietic specific gene encoding a small GTP binding protein is overexpressed during T cell activation.

    Reibel L, Dorseuil O, Stancou R, Bertoglio J, Gacon G.

    Source

    Institut Cochin de Génétique Moléculaire, INSERM U. 257, Paris, France.

    Abstract

    We have isolated, from a human B cell line cDNA library, a cDNA (Gx) encoding a small G protein identical to rac 2, a member of the ras superfamily. Gx/rac 2 gene is expressed as a unique mRNA of 1,7 Kb in peripheral blood lymphocytes, in purified B and T cells, in thymus as well as in several B and T cell lines. It is not expressed in many other tissues analysed including liver, brain, lung, heart and kidney. Upon in vitro stimulation with phytohemagglutinin A, peripheral blood lymphocytes show a clear increase of the Gx/rac 2 mRNA after 6 hours; a 30-50 fold accumulation is reached at 24 hours and persists thereafter. Purified T lymphocytes exhibit a similar increase in Gx/rac 2 mRNA expression upon mitogenic stimulation. Therefore, the expression of the Gx/rac 2 gene appears to be restricted to cells of the hemopoietic lineage and to be strongly stimulated during T cell activation. Gx/rac 2 protein must fulfill a specific role in activated T cells that could provide a new model for studying the function of small G proteins.

    PMID:
    1902092
    [PubMed - indexed for MEDLINE]

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