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Eur J Clin Nutr. 2009 Jun;63(6):802-4. doi: 10.1038/ejcn.2008.55. Epub 2008 Nov 19.

Maternal 25-hydroxyvitamin D concentration and offspring birth size: effect modification by infant VDR genotype.

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  • 1Clinical Epidemiology and Biostatistics Unit, Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia. ruth.morley@mcri.edu.au



We tested the hypothesis that the relationship between maternal 25-hydroxyvitamin D (25-(OH)D) and offspring birth size differs according to offspring vitamin D receptor (VDR) genotype (Apa1, Bsm1, Fok1 or Taq1).


Mothers of 354 singleton babies had serum 25-(OH)D concentration measured at 28-30 weeks of gestation and consented to measurement of their babies soon after birth. DNA was extracted from the babies' Guthrie cards.


There was evidence of effect modification by infant FokI genotype. Babies of deficient mothers had lower birth weight with FF or Ff, but not ff genotype (P-value for interaction after adjustment for potential confounding factors=0.02), but thicker subscapular and suprailiac skinfolds with ff, but not FF or Ff genotype (P=0.008 and 0.02, respectively). Sample size was insufficient to investigate effect modification by the other VDR polymorphisms.


These preliminary findings suggest that studies of maternal vitamin D status and birth size may need to take VDR genotype into account.

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