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Eur J Clin Nutr. 2009 Jun;63(6):802-4. doi: 10.1038/ejcn.2008.55. Epub 2008 Nov 19.

Maternal 25-hydroxyvitamin D concentration and offspring birth size: effect modification by infant VDR genotype.

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  • 1Clinical Epidemiology and Biostatistics Unit, Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia. ruth.morley@mcri.edu.au

Abstract

BACKGROUND/OBJECTIVES:

We tested the hypothesis that the relationship between maternal 25-hydroxyvitamin D (25-(OH)D) and offspring birth size differs according to offspring vitamin D receptor (VDR) genotype (Apa1, Bsm1, Fok1 or Taq1).

SUBJECTS/METHODS:

Mothers of 354 singleton babies had serum 25-(OH)D concentration measured at 28-30 weeks of gestation and consented to measurement of their babies soon after birth. DNA was extracted from the babies' Guthrie cards.

RESULTS:

There was evidence of effect modification by infant FokI genotype. Babies of deficient mothers had lower birth weight with FF or Ff, but not ff genotype (P-value for interaction after adjustment for potential confounding factors=0.02), but thicker subscapular and suprailiac skinfolds with ff, but not FF or Ff genotype (P=0.008 and 0.02, respectively). Sample size was insufficient to investigate effect modification by the other VDR polymorphisms.

CONCLUSIONS:

These preliminary findings suggest that studies of maternal vitamin D status and birth size may need to take VDR genotype into account.

PMID:
19018272
[PubMed - indexed for MEDLINE]
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