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Gut. 2009 Apr;58(4):586-93. doi: 10.1136/gut.2008.162859. Epub 2008 Nov 18.

Dietary modulation of peroxisome proliferator-activated receptor gamma.

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  • 1Appareil Digestif Environnement Nutrition (ADEN EA 4311), Faculté de Médecine-Pharmacie, Institut Fédératif de Recherches Multidisciplinaires sur les Peptides (IFR23), 22, boulevard Gambetta, 76183 Rouen cedex, France.


Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor that regulates intestinal inflammation. PPAR gamma is highly expressed in the colon and can be activated by various dietary ligands. A number of fatty acids such as polyunsaturated fatty acids or eicosanoids are considered as endogenous PPAR gamma activators. Nevertheless, other nutrients such as glutamine, spicy food or flavonoids are also able to activate PPAR gamma. As PPAR gamma plays a key role in bacterial induced inflammation, anti-inflammatory properties of probiotics may be mediated through PPAR gamma. The aims of the present review are to discuss of the potential roles of dietary compounds in modulating intestinal inflammation through PPAR gamma.

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