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1: Int J Tuberc Lung Dis. 2008 Dec;12(12):1376-9.Click here to read Links

Consensus statement on the revised World Health Organization recommendations for BCG vaccination in HIV-infected infants.

Hesseling AC, Cotton MF, Fordham von Reyn C, Graham SM, Gie RP, Hussey GD.

Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Tygerberg, South Africa. annekeh@sun.ac.za

This document outlines the consensus agreement from the Union's BCG Working Group regarding BCG vaccination in HIV-infected infants, in response to recently revised World Health Organization (WHO) guidelines, which make HIV infection in infants a full contraindication to bacille Calmette-Guérin (BCG) vaccination. BCG is one of the most widely given vaccines globally and is safe in immunocompetent individuals. Recent evidence shows that HIV-infected infants who were routinely vaccinated with BCG at birth, when asymptomatic, and who later developed AIDS, are at high risk of developing disseminated BCG disease (estimated incidence 407-1300 per 100 000). The document outlines requirements to implement selective BCG vaccination strategies in infants born to HIV-infected women and strategies to reduce the risk of vertical HIV transmission and disseminated BCG disease in infants.

PMID: 19017445 [PubMed - indexed for MEDLINE]

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