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Br J Dermatol. 2009 Jan;160(1):183-5. doi: 10.1111/j.1365-2133.2008.08905.x. Epub 2008 Oct 25.

Biomarkers of Th2 polarity are predictive of staphylococcal colonization in subjects with atopic dermatitis.

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  • 1Department of Dermatology, Johns Hopkins Medical Institution, Baltimore, MD 21224, USA.

Abstract

BACKGROUND:

Staphylococcal colonization of the skin is commonly observed in subjects with atopic dermatitis (AD) and correlates with disease severity. Little is known about whether the degree of T-helper 2 (Th2) polarity in these subjects can also affect the frequency of bacterial colonization in this disease.

OBJECTIVES:

To determine if there is a correlation between markers of Th2 polarity [serum total IgE, eosinophilia and presence of another atopic disease (allergic rhinitis)] and skin colonization with Staphylococcus aureus in subjects with AD.

METHODS:

A retrospective chart review was performed of an academic dermatology clinic focused on the treatment of AD with a single provider.

RESULTS:

Staphylococcus aureus colonization was more commonly observed in subjects with AD who had peripheral eosinophilia, elevated serum IgE levels, and/or a history of or active allergic rhinitis.

CONCLUSIONS:

Results suggest that Th2 polarity may enhance subjects' risk for bacterial colonization.

PMID:
19016695
[PubMed - indexed for MEDLINE]
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