Soc Cogn Affect Neurosci. 2008 Jun;3(2):135-43. Epub 2008 Mar 3.

Abnormal cerebral effective connectivity during explicit emotional processing in adults with autism spectrum disorder.

Wicker B, Fonlupt P, Hubert B, Tardif C, Gepner B, Deruelle C.

Source

Mediterranean Institute of Cognitive Neurosciences, Centre National de la Recherche Scientifique, Université de la Méditerranée, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France. wicker@incm.cnrs-mrs.fr

Abstract

Several recent studies suggest that autism may result from abnormal communication between brain regions. We directly assessed this hypothesis by testing the presence of abnormalities in a model of the functional cerebral network engaged during explicit emotion processing in adults with high functioning autism or Asperger syndrome. Comparison of structural equation models revealed abnormal patterns of effective connectivity, with the prefrontal cortex as a key site of dysfunction. These findings provide evidence that abnormal long-range connectivity between structures of the 'social brain' could explain the socio-emotional troubles that characterize the autistic pathology.

PMID:: 19015104; [PubMed - indexed for MEDLINE]
PMCID:: PMC2555468

Free PMC Article

Images from this publication.See all images (2) Free text

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Autism - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

The functional neuroanatomy of social behaviour: changes in cerebral blood flow when people with autistic disorder process facial expressions. [Brain. 2000]
The functional neuroanatomy of social behaviour: changes in cerebral blood flow when people with autistic disorder process facial expressions.
Critchley HD, Daly EM, Bullmore ET, Williams SC, Van Amelsvoort T, Robertson DM, Rowe A, Phillips M, McAlonan G, Howlin P, et al. Brain. 2000 Nov; 123 ( Pt 11):2203-12.
Abnormal spatiotemporal processing of emotional facial expressions in childhood autism: dipole source analysis of event-related potentials. [Eur J Neurosci. 2008]
Abnormal spatiotemporal processing of emotional facial expressions in childhood autism: dipole source analysis of event-related potentials.
Wong TK, Fung PC, Chua SE, McAlonan GM. Eur J Neurosci. 2008 Jul; 28(2):407-16.
Review The orbitofrontal-amygdala circuit and self-regulation of social-emotional behavior in autism. [Neurosci Biobehav Rev. 2006]
Review The orbitofrontal-amygdala circuit and self-regulation of social-emotional behavior in autism.
Bachevalier J, Loveland KA. Neurosci Biobehav Rev. 2006; 30(1):97-117. Epub 2005 Sep 12.
Amygdala volume and nonverbal social impairment in adolescent and adult males with autism. [Arch Gen Psychiatry. 2006]
Amygdala volume and nonverbal social impairment in adolescent and adult males with autism.
Nacewicz BM, Dalton KM, Johnstone T, Long MT, McAuliff EM, Oakes TR, Alexander AL, Davidson RJ. Arch Gen Psychiatry. 2006 Dec; 63(12):1417-28.
Review [Neural mechanism underlying autistic savant and acquired savant syndrome]. [Brain Nerve. 2008]
Review [Neural mechanism underlying autistic savant and acquired savant syndrome].
Takahata K, Kato M. Brain Nerve. 2008 Jul; 60(7):861-9.

See reviews... See all...

Cited by 5 PubMed Central articles

Imaging-genetics in autism spectrum disorder: advances, translational impact, and future directions. [Front Psychiatry. 2012]
Imaging-genetics in autism spectrum disorder: advances, translational impact, and future directions.
Ameis SH, Szatmari P. Front Psychiatry. 2012; 3:46. Epub 2012 May 15.
Impaired structural connectivity of socio-emotional circuits in autism spectrum disorders: a diffusion tensor imaging study. [PLoS One. 2011]
Impaired structural connectivity of socio-emotional circuits in autism spectrum disorders: a diffusion tensor imaging study.
Ameis SH, Fan J, Rockel C, Voineskos AN, Lobaugh NJ, Soorya L, Wang AT, Hollander E, Anagnostou E. PLoS One. 2011; 6(11):e28044. Epub 2011 Nov 23.
Inter-regional brain communication and its disturbance in autism. [Front Syst Neurosci. 2011]
Inter-regional brain communication and its disturbance in autism.
Schipul SE, Keller TA, Just MA. Front Syst Neurosci. 2011 Feb 22; 5:10. Epub 2011 Feb 22.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Abnormal cerebral effective connectivity during explicit emotional processing in...
Abnormal cerebral effective connectivity during explicit emotional processing in adults with autism spectrum disorder.
Soc Cogn Affect Neurosci. 2008 Jun ;3(2):135-43. Epub 2008 Mar 3 .

PubMed
Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with...
Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting.
Soc Cogn Affect Neurosci. 2008 Jun ;3(2):128-34. Epub 2008 Feb 11 .

PubMed
Hypokinesia, rigidity, and tremor induced by hypothalamic 6-OHDA lesions in the ...
Hypokinesia, rigidity, and tremor induced by hypothalamic 6-OHDA lesions in the rat.
Brain Res Bull. 1991 Feb ;26(2):317-20.

PubMed
The neural correlates of trait resilience when anticipating and recovering from ...
The neural correlates of trait resilience when anticipating and recovering from threat.
Soc Cogn Affect Neurosci. 2008 Dec ;3(4):322-32. Epub 2008 Sep 2 .

PubMed
Structure and dynamics of single DNA molecules manipulated by magnetic tweezers ...
Structure and dynamics of single DNA molecules manipulated by magnetic tweezers and or flow.
Methods. 2009 Mar ;47(3):214-22. Epub 2008 Nov 17 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Abnormal cerebral effective connectivity during explicit emotional processing in adults with autism spectrum disorder.

Source

Abstract

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 5 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information