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Genomics. 2009 Mar;93(3):235-42. doi: 10.1016/j.ygeno.2008.10.006. Epub 2008 Dec 10.

Multi-stage analysis of gene expression and transcription regulation in C57/B6 mouse liver development.

Author information

  • 1TNLIST/Department of Automation, MOE Key Laboratory of Bioinformatics and Bioinformatics Division, Tsinghua University, Beijing, China.

Abstract

The liver performs a number of essential functions for life. The development of such a complex organ relies on finely regulated gene expression profiles which change over time in the development and determine the phenotype and function of the liver. We used high-density oligonucleotide microarrays to study the gene expression and transcription regulation at 14 time points across the C57/B6 mouse liver development, which include E11.5 (embryonic day 11.5), E12.5, E13.5, E14.5, E15.5, E16.5, E17.5, E18.5, Day0 (the day of birth), Day3, Day7, Day14, Day21, and normal adult liver. With these data, we made a comprehensive analysis on gene expression patterns, functional preferences and transcriptional regulations during the liver development. A group of uncharacterized genes which might be involved in the fetal hematopoiesis were detected.

PMID:
19015022
[PubMed - indexed for MEDLINE]
PMCID:
PMC2995988
Free PMC Article

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