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Fertil Steril. 2010 Jan;93(1):199-209. doi: 10.1016/j.fertnstert.2008.10.001. Epub 2008 Nov 14.

Pregnancy outcome after magnetic resonance-guided focused ultrasound surgery (MRgFUS) for conservative treatment of uterine fibroids.

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  • 1Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel.

Abstract

OBJECTIVE:

To report all pregnancies to date after magnetic resonance-guided focused ultrasound surgery (MRgFUS) for the conservative treatment of clinically significant uterine fibroids.

DESIGN:

Prospective registry of all known pregnancies occurring after MRgFUS maintained by the device manufacturer and reported to the Food and Drug Administration.

SETTING:

World experience of pregnancies after treatment with reports from 13 sites in seven countries.

PATIENT(S):

Fifty-one reproductive-age women with uterine leiomyomas.

INTERVENTION(S):

Women underwent MRgFUS treatment for symptomatic uterine leiomyomas before this report.

MAIN OUTCOME MEASURE(S):

Pregnancy outcomes and complications.

RESULT(S):

Fifty-four pregnancies in 51 women have occurred after MRgFUS treatment of uterine leiomyomas. The mean time to conception was 8 months after treatment. Live births occurred in 41% of pregnancies, with a 28% spontaneous abortion rate, an 11% rate of elective pregnancy termination, and 11 (20%) ongoing pregnancies beyond 20 gestational weeks. The mean birth weight was 3.3 kg, and the vaginal delivery rate was 64%.

CONCLUSION(S):

Preliminary pregnancy experience after MRgFUS is encouraging, with a high rate of delivered and ongoing pregnancies.

Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

PMID:
19013566
[PubMed - indexed for MEDLINE]
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