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Genome Biol. 2008;9(11):240. doi: 10.1186/gb-2008-9-11-240. Epub 2008 Nov 4.

Divergence in cis-regulatory networks: taking the 'species' out of cross-species analysis.

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  • 1European Molecular Biology Laboratory, D-69117 Heidelberg, Germany.

Abstract

Many essential transcription factors have conserved roles in regulating biological programs, yet their genomic occupancy can diverge significantly. A new study demonstrates that such variations are primarily due to cis-regulatory sequences, rather than differences between the regulators or nuclear environments.

PMID:
19012800
[PubMed - indexed for MEDLINE]
PMCID:
PMC2614484
Free PMC Article
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