Genome Biol. 2008;9(11):240. Epub 2008 Nov 4.

Divergence in cis-regulatory networks: taking the 'species' out of cross-species analysis.

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European Molecular Biology Laboratory, D-69117 Heidelberg, Germany.

Abstract

Many essential transcription factors have conserved roles in regulating biological programs, yet their genomic occupancy can diverge significantly. A new study demonstrates that such variations are primarily due to cis-regulatory sequences, rather than differences between the regulators or nuclear environments.

PMID:: 19012800; [PubMed - indexed for MEDLINE]
PMCID:: PMC2614484

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