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J Org Chem. 2009 Jan 2;74(1):463-5. doi: 10.1021/jo802248g.

Synthesis of 6,7,8-trisubstituted purines via a copper-catalyzed amidation reaction.

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  • 1UMR 176, Institut Curie, Bât. 110-112, Centre Universitaire, 91405 Orsay, France.

Abstract

We report herein an efficient method for the synthesis of 6,7,8-trisubstituted purines via a copper-catalyzed amidation reaction from easily accessible starting materials. Furthermore, the resulting 6-benzylsulfanyl-substituted purine derivatives may be readily oxidized for substitution by nucleophiles to give access to 6,7,8-trisubstituted purines for biological screening purposes.

PMID:
19012431
[PubMed - indexed for MEDLINE]
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