Mammographic density estimation: comparison among BI-RADS categories, a semi-automated software and a fully automated one

Breast. 2009 Feb;18(1):35-40. doi: 10.1016/j.breast.2008.09.005. Epub 2008 Nov 17.

Abstract

Although breast density is considered a strong predictor of breast cancer risk, its quantitative assessment is difficult. The aim of this study is to demonstrate that breast density assessment with a fully automated software is feasible and correlates with the semi-automated evaluation and the quantitative BI-RADS standards. A data set of 160 mammograms was evaluated by three blinded radiologists. Intra-observer (reader 1: k=0.71; reader 2: k=0.76; reader 3: k=0.62) and inter-observer (reader 1 vs reader 2: k=0.72; reader 2 vs reader 3: k=0.80; reader 3 vs reader 1: k=0.72) variability for the semi-automated software were good on a four-grade scale (D1/D2/D3/D4) and correlated with BI-RADS evaluation made by other two blinded radiologists (r=0.65, p<0.01). Inter-observer (reader 1 vs reader 2: k=0.85; reader 2 vs reader 3: k=0.91; reader 3 vs reader 1: k=0.85) variability for the semi-automated software was very good on a two-grade scale (D1-D2/D3-D4). The use of the fully automated software eliminated intra- and inter-observer differences, correlated with BI-RADS categories (r=0.62, p<0.01) and can replace the semi-automated one (Bland-Altman statistics). Our study demonstrates that automated estimation of breast density is feasible and eliminates subjectivity. Furthermore both the semi-automated and the fully automated density estimation are more accurate than BI-RADS quantitative evaluation and could also be used in the daily clinical practice.

Publication types

  • Comparative Study

MeSH terms

  • Algorithms
  • Breast Neoplasms / diagnostic imaging
  • Female
  • Humans
  • Mammography / classification
  • Mammography / standards*
  • Observer Variation
  • Radiographic Image Interpretation, Computer-Assisted / instrumentation
  • Radiographic Image Interpretation, Computer-Assisted / standards*
  • Reproducibility of Results
  • Software