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Mol Cell Endocrinol. 2009 Feb 5;299(1):58-63. doi: 10.1016/j.mce.2008.10.018. Epub 2008 Nov 1.

Dietary activators of Sirt1.

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  • 1Laboratory of Experimental Gerontology, National Institute on Aging, 6200 Seaforth Street, National Institutes of Health, Baltimore, MD 21224, USA.

Abstract

Calorie restriction (CR) is a non-genetic manipulation that reliably results in extended lifespan of several species ranging from yeast to dogs. The lifespan extension effect of CR has been strongly associated with an increased level and activation of the silent information regulator 2 (Sir2) histone deacetylase and its mammalian ortholog Sirt1. This association led to the search for potential Sirt1-activating, life-extending molecules. This review briefly outlines the experimental findings on resveratrol and other dietary activators of Sirt1.

PMID:
19010386
[PubMed - indexed for MEDLINE]
PMCID:
PMC2727669
Free PMC Article
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