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1: Kidney Int. 2008 Dec;74(11):1371-3.Click here to read Links
Comment on:
Kidney Int. 2008 Dec;74(11):1394-402.

Expanding targets of vitamin D receptor activation: downregulation of several RAS components in the kidney.

Pörsti IH.

Medical School, University of Tampere, Department of Internal Medicine, Tampere University Hospital, Tampere, Finland. ilkka.porsti@uta.fi

Vitamin D receptor (VDR) activation has a beneficial influence on the progression of experimental renal insufficiency, and reduced renal tissue renin expression may play a role in this process. Freundlich and co-workers now report that VDR activation also suppresses the expression of angiotensinogen, angiotensin II type 1 receptor, and renin receptor in the kidneys of 5/6 nephrectomized rats, effects associated with reduced blood pressure and urinary protein excretion and with alleviated renal tissue damage.

PMID: 19008907 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Calcitriol (Rocaltrol® )

    Calcitriol is a form of vitamin D that is used to treat and prevent low levels of calcium in the blood of patients whose kidneys or parathyroid glands (glands in the neck that release natural substances to control the am...

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